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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclooxygenase (COX)-Phosphosulindac
Phosphosulindac

Chemical Structure : Phosphosulindac

CAS No.: 1118973-90-2

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Phosphosulindac (Phospho-sulindac, OXT-328)

货号: PC-27218Not For Human Use, Lab Use Only.

Phosphosulindac (Phospho-sulindac, OXT-328) is a sulindac derivative and potential anti-cancer and anti-inflammatory agent, is effective in colon cancer and non-small-cell lung cancer (NSCLC).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Phosphosulindac (Phospho-sulindac, OXT-328) is a sulindac derivative and potential anti-cancer and anti-inflammatory agent, is effective in colon cancer and non-small-cell lung cancer (NSCLC).
Phosphosulindac (Phospho-sulindac, OXT-328) inhibits growth of cultured HCCCs and more efficacious in preventing the growth of HT-29 xenografts in nude mice.
Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts. phospho-sulindac suppressed lung tumorigenesis.
Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice, inhibits EGFR-dependent survival cascades in NSCLC cells and induces oxidative stress to ultimately induce apoptosis/autophagy.

物理化学性质&存储条件

分子量 564.61
分子式 C28H34FO7PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((diethoxyphosphoryl)oxy)butyl (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetate

参考文献

1. Xie G, et al. Br J Pharmacol. 2012 Apr;165(7):2152-66.

2. Mackenzie GG, et al. Gastroenterology. 2010 Oct;139(4):1320-32.

3. Sun Y, et al. Cancer Res. 2008 Oct 15;68(20):8269-77.

4. Cheng KW, et al. Mol Cancer Ther. 2013 Aug;12(8):1417-28.

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