Phortress |CAS:328087-38-3 Probechem Biochemicals

Chemical Structure : Phortress

CAS No.: 328087-38-3

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Phortress (NSC 710305;NSC710305)

货号: PC-60777Not For Human Use, Lab Use Only.

Phortress (NSC710305) is the L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3580	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Phortress (NSC710305) is the L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
Phortress (NSC710305) causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells.
Phortress (NSC710305) induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.

物理化学性质&存储条件

分子量	459.405
分子式	C20H25Cl2FN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride

参考文献

1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46.

2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.

3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605.

4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.

Phortress (NSC 710305;NSC710305)

生物&药学活性

物理化学性质&存储条件

参考文献

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Phortress (NSC 710305;NSC710305)

生物&药学活性

物理化学性质&存储条件

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