Phenylacetamide 2 | FFA2 agonist | Probechem Biochemicals

Chemical Structure : Phenylacetamide 2

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Phenylacetamide 2 (FFA2 allosteric agonist 2)

货号: PC-20441Not For Human Use, Lab Use Only.

Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively.

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生物&药学活性

Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively.
Phenylacetamide 2 is inactive against a panel of GPCRs that included FFA1, FFA3, GPR109A, growth hormone secretagogue receptor, endothelin type B receptor, CCR2, CXCR3, CXCR4, and CCR7 at 30 uM.
Phenylacetamide 2 is capable of activating both Gαq- and Gαi -coupled pathways for receptor function.
Phenylacetamide 2 inhibits lipolysis in 3T3L1 adipocytes in a concentration-dependent manner as measured by the reduction of glycerol production in adipocytes.

物理化学性质&存储条件

分子量	312.79
分子式	C14H14ClFN2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)-3-methylbutanamide

参考文献

1. Taeweon Lee, et al. Mol Pharmacol. 2008 Dec;74(6):1599-609.

Phenylacetamide 2 (FFA2 allosteric agonist 2)

生物&药学活性

物理化学性质&存储条件

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Phenylacetamide 2 (FFA2 allosteric agonist 2)

生物&药学活性

物理化学性质&存储条件

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