Ph-HTBA

Chemical Structure : Ph-HTBA

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货号: PC-49435Not For Human Use, Lab Use Only.

Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.

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100 mg		Get quote

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生物&药学活性

Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.
Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice.
Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development.
Ph-HTBA reduces Ca2+-stimulated CaMKIIα Thr286 autophosphorylation in primary cortical neurons and substrate phosphorylation of recombinant CaMKIIα, potentially contributing to its neuroprotective effect.

物理化学性质&存储条件

分子量	294.350
分子式	C19H18O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(5-Hydroxy-2-phenyl-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-ylidene)acetic acid

参考文献

1. Tian Y, et al. J Med Chem. 2022 Nov 8. doi: 10.1021/acs.jmedchem.2c00805.

2. Griem-Krey N, et al. Biomed Pharmacother. 2022 Oct 20;156:113895.

Ph-HTBA

生物&药学活性

物理化学性质&存储条件

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Ph-HTBA

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物理化学性质&存储条件

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