Pexidartinib (PLX3397) | CSF1R inhibitor | Probechem Biochemicals

Chemical Structure : Pexidartinib

CAS No.: 1029044-16-3

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Pexidartinib (PLX-3397, PLX3397)

货号: PC-45069Not For Human Use, Lab Use Only.

Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.

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10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.
Pexidartinib (PLX3397) inhibits the CSF1-dependent proliferation with IC50 of 0.44 uM, 0.22 uMand 0.1 uM in M-NFS-60, Bac1.2F5 and M-07e cells, respectively.
Pexidartinib (PLX3397) significantly inhibits PTX-induced tumor infiltration in mice.

物理化学性质&存储条件

分子量	417.8148
分子式	C20H15ClF3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	3-Pyridinemethanamine, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-

参考文献

1. DeNardo DG, et al. Cancer Discov. 2011 Jun;1(1):54-67.

2. Coniglio SJ, et al. Mol Med. 2012 May 9;18:519-27.

3. Chitu V, et al. Blood. 2012 Oct 11;120(15):3126-35.

Pexidartinib (PLX-3397, PLX3397)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pexidartinib (PLX-3397, PLX3397)

生物&药学活性

物理化学性质&存储条件

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