Perforin inhibitor 16 | Perforin inhibitor | Probechem Biochemicals

Chemical Structure : Perforin inhibitor 16

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Perforin inhibitor 16 (Perforin-IN-16)

货号: PC-73073Not For Human Use, Lab Use Only.

Perforin inhibitor 16 (Perforin-IN-16) is a small molecule Perforin inhibitor with IC50 of 1.13 uM in KHYG1 assay.

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生物&药学活性

Perforin inhibitor 16 (Perforin-IN-16) is a small molecule Perforin inhibitor with IC50 of 1.13 uM in KHYG1 assay.
Perforin inhibitor 16 preserves transferred MHC-mismatched cells in a short term mouse
model of bone marrow stem cell transplantation.
Perforin inhibitor 16 is the first reported small molecule able to prevent rejection of transplanted bone marrow stem cells in vivo by blocking perforin function.
Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate virus-infected and transformed target cells.

物理化学性质&存储条件

分子量	528.549
分子式	C24H18F2N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-difluoro-N-(2-methoxy-5-(5-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide

参考文献

1. Spicer JA, et al. J Med Chem. 2020 Mar 12;63(5):2229-2239.

Perforin inhibitor 16 (Perforin-IN-16)

生物&药学活性

物理化学性质&存储条件

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Perforin inhibitor 16 (Perforin-IN-16)

生物&药学活性

物理化学性质&存储条件

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