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Peretinoin

Chemical Structure : Peretinoin

CAS No.: 81485-25-8

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Peretinoin (NIK-333, NIK333)

货号: PC-42023Not For Human Use, Lab Use Only.

Peretinoin (NIK333) is an orally available, synthetic retinoid with potential antineoplastic and chemopreventive activities.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Peretinoin (NIK333) is an orally available, synthetic retinoid with potential antineoplastic and chemopreventive activities.
Peretinoin inhibits DEN-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation.
Peretinoin decreases the levels of cyclin D1, cyclin D2, cIAP2 and XIAP proteins, and inhibits growth of ATL cells both in vitro and in vivo.
Peretinoin prevents the progression of NASH and the development of HCC through activating the autophagy pathway by increased Atg16L1 expression in mice model.
Peretinoin also inhibits HCV replication and infectious virus release in vitro.

物理化学性质&存储条件

分子量 302.451
分子式 C20H30O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 100 mg/mL; In vivo: Peretinoin is dissolved in DMSO (3 mg/mL) and then diluted with water (DMSO: water=1:1).
Chemical Name/SMILES

2,4,6,10,14-Hexadecapentaenoic acid, 3,7,11,15-tetramethyl-, (2E,4E,6E,10E)-

参考文献

1. Kagawa M, et al. Carcinogenesis. 2004 Jun;25(6):979-85.

2. Okudaira T, et al. Mol Cancer Ther. 2006 Mar;5(3):704-12.

3. Shimakami T, et al. Sci Rep. 2014 Apr 15;4:4688.

4. Okada H, et al. Oncotarget. 2017 Jun 20;8(25):39978-39993.

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