Peptide P60 | FOXP3 inhibitor | Probechem Biochemicals

Chemical Structure : Peptide P60

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Peptide P60 (FOXP3 inhibitor P60)

货号: PC-63521Not For Human Use, Lab Use Only.

Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3, exhibits functional inhibition of Treg in vitro and in vivo.

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生物&药学活性

Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3, exhibits functional inhibition of Treg in vitro and in vivo.
Peptide P60 inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT.
Peptide P60 inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation.
Peptide P60 induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.

物理化学性质&存储条件

分子量	1994.369
分子式	C95H132N24O20S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-Met

参考文献

1. Casares N, et al. J Immunol. 2010 Nov 1;185(9):5150-9.

Peptide P60 (FOXP3 inhibitor P60)

生物&药学活性

物理化学性质&存储条件

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Peptide P60 (FOXP3 inhibitor P60)

生物&药学活性

物理化学性质&存储条件

参考文献

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