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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-Pemetrexed
Pemetrexed

Chemical Structure : Pemetrexed

CAS No.: 137281-23-3

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Pemetrexed (LY231514;LY 231514;LY-231514)

货号: PC-42709Not For Human Use, Lab Use Only.

A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.

Chemotherapeutic Agents

Approved

物理化学性质&存储条件

分子量 427.4106
分子式 C20H21N5O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in H2O
Chemical Name/SMILES

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

参考文献

1. Shih C, et al. Cancer Res. 1997 Mar 15;57(6):1116-23.

2. Tonkinson JL, et al. Cancer Res. 1999 Aug 1;59(15):3671-6.

3. Curtin NJ, et al. Lancet Oncol. 2001 May;2(5):298-306.

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