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首页-抗体和重组蛋白-Biosimilar Antibody-Pembrolizumab
Pembrolizumab

Chemical Structure : Pembrolizumab

CAS No.: 1374853-91-4

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Pembrolizumab (Anti-human PD-1 mAb, human IgG4 (S228P)-Kappa; MK-3475)

货号: PC-Ab1031Not For Human Use, Lab Use Only.

Pembrolizumab was the first anti-PD-1 antibody to be approved by the US Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma with disease progression following ipilimumab, and if BRAF (V600) mutation positive, a BRAF inhibitor. Pembrolizumab has also received breakthrough status for the treatment of EGFR mutation-negative, ALK rearrangement-negative non-small cell lung cancer (NSCLC) that has progressed on or following platinum-based chemotherapy. .

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pembrolizumab was the first anti-PD-1 antibody to be approved by the US Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma with disease progression following ipilimumab, and if BRAF (V600) mutation positive, a BRAF inhibitor. Pembrolizumab has also received breakthrough status for the treatment of EGFR mutation-negative, ALK rearrangement-negative non-small cell lung cancer (NSCLC) that has progressed on or following platinum-based chemotherapy.

物理化学性质&存储条件

分子量
分子式 Human IgG4 (S228P)-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Pembrolizumab; Keytruda; MK3475; MK-3475; MK 3475; CD279; programmed death-1; programmed death 1 ; PD1; PD 1; Programmed cell death protein 1; hPD-1; hPD1; hPD 1

参考文献

1. 1, Robert C, et al. N Engl J Med. 2015 Jun 25;372(26):2521-32. 2, Herbst RS, et al. Lancet. 2016 Apr 9;387(10027):1540-1550. 3, Tumeh PC, et al. Nature. 2014 Nov 27;515(7528):568-71. 4, Hamid O, et al. N Engl J Med. 2013 Jul 11;369(2):134-44.

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