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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Pazopanib (GW786034)
Pazopanib (GW786034)

Chemical Structure : Pazopanib (GW786034)

CAS No.: 444731-52-6

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Pazopanib (GW786034) (GW786034B, GW786034)

货号: PC-42453Not For Human Use, Lab Use Only.

Pazopanib (GW786034) is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.

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100 mg ￥1180 In stock
250 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pazopanib (GW786034) is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
Pazopanib also shows significant activity against the closely related RTKs PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50 of 84, 74, 140, and 146 nM, respectively.
Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR-2 in HUVEC cells with IC50 of 8 nM.
Pazopanib inhibits in vivo tumor growth, increases MM cell apoptosis, decreases angiogenesis, and prolongs host survival in a xenograft model of human MM.

物理化学性质&存储条件

分子量 437.518
分子式 C21H23N7O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 43 mg/mL
Chemical Name/SMILES

Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-

参考文献

1. Podar K, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19478-83.

2. Kumar R, et al. Mol Cancer Ther. 2007 Jul;6(7):2012-21.

3. Harris PA, et al. J Med Chem. 2008 Aug 14;51(15):4632-40.

4. Hurwitz HI, et al. Clin Cancer Res. 2009 Jun 15;15(12):4220-7.

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