Chemical Structure : Pavurutamab
货号: PC-38864Not For Human Use, Lab Use Only.
Pavurutamab (AMG 701) is a half-life extended anti-BCMA BiTE (bispecific T-cell engager) recombinant antibody, induces selective cytotoxicity against BCMA-expressing MM cells (EC50=18.8 pM), T-cell activation, and cytokine release in vitro and in vivo.
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Pavurutamab (AMG 701) is a half-life extended anti-BCMA BiTE (bispecific T-cell engager) recombinant antibody, induces selective cytotoxicity against BCMA-expressing MM cells (EC50=18.8 pM), T-cell activation, and cytokine release in vitro and in vivo.
Pavurutamab (AMG 701) completely inhibited tumor formation, as well as inhibited growth of established tumors and extended survival in an orthotopic MM model.
Combination with a programmed cell death protein 1 (PD-1)-blocking antibody significantly increased AMG 701 potency in vitro.
Isotype: Immunoglobulin scFv-scFv-scFc.
Anti-[human TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)] and anti-[human CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific.
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外观性状 | Solid | |
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Solubility |
10 mM in DMSO |
1. Goldstein RL, et al. Blood Adv. 2020 Sep 8;4(17):4180-4194.
2. Cho SF, et al. Blood Adv. 2020 Sep 8;4(17):4195-4207.
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