Pavurutamab | BCMA/CD3 BiTE antibody | Probechem Biochemicals

Chemical Structure : Pavurutamab

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Pavurutamab (AMG 701)

货号: PC-38864Not For Human Use, Lab Use Only.

规格	价格	库存	数量
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Pavurutamab (AMG 701) is a half-life extended anti-BCMA BiTE (bispecific T-cell engager) recombinant antibody, induces selective cytotoxicity against BCMA-expressing MM cells (EC50=18.8 pM), T-cell activation, and cytokine release in vitro and in vivo.
Pavurutamab (AMG 701) completely inhibited tumor formation, as well as inhibited growth of established tumors and extended survival in an orthotopic MM model.
Combination with a programmed cell death protein 1 (PD-1)-blocking antibody significantly increased AMG 701 potency in vitro.

Isotype: Immunoglobulin scFv-scFv-scFc.

Anti-[human TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)] and anti-[human CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Goldstein RL, et al. Blood Adv. 2020 Sep 8;4(17):4180-4194.

2. Cho SF, et al. Blood Adv. 2020 Sep 8;4(17):4195-4207.

Pavurutamab (AMG 701)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pavurutamab (AMG 701)

生物&药学活性

物理化学性质&存储条件

参考文献

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