Pasireotide acetate | SSTR agonist | Probechem Biochemicals

Chemical Structure : Pasireotide acetate

CAS No.: 396091-76-2

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Pasireotide acetate (SOM230 acetate, SOM-230 acetate)

货号: PC-22363Not For Human Use, Lab Use Only.

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10 mg	￥4280	In stock
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生物&药学活性

Pasireotide (SOM230) acetate is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
Pasireotide (SOM230) effectively inhibits GHRH-induced growth hormone release in primary cultures of rat pituitary cells with IC50 of 0.4 nM.
Pasireotide (SOM230) also potently suppresses GH secretion in rats.

物理化学性质&存储条件

分子量	1107.28
分子式	C60H70N10O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	acetic acid;[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate

参考文献

1. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

2. Bruns C, et al. Eur J Endocrinol. 2002 May;146(5):707-16.

3. Hofland LJ, et al. Eur J Endocrinol. 2005 Apr;152(4):645-54.

Pasireotide acetate (SOM230 acetate, SOM-230 acetate)

生物&药学活性

物理化学性质&存储条件

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Pasireotide acetate (SOM230 acetate, SOM-230 acetate)

生物&药学活性

物理化学性质&存储条件

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