Pasireotide | SSTR agonist | Probechem Biochemicals

Chemical Structure : Pasireotide

CAS No.: 396091-73-9

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Pasireotide (SOM-230, SOM320)

货号: PC-44950Not For Human Use, Lab Use Only.

A potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).

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生物&药学活性

Pasireotide (SOM230) is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
Pasireotide (SOM230) effectively inhibits GHRH-induced growth hormone release in primary cultures of rat pituitary cells with IC50 of 0.4 nM.
Pasireotide (SOM230) also potently suppresses GH secretion in rats.

物理化学性质&存储条件

分子量	1047.206
分子式	C58H66N10O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl]

参考文献

1. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

2. Bruns C, et al. Eur J Endocrinol. 2002 May;146(5):707-16.

3. Hofland LJ, et al. Eur J Endocrinol. 2005 Apr;152(4):645-54.

Pasireotide (SOM-230, SOM320)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pasireotide (SOM-230, SOM320)

生物&药学活性

物理化学性质&存储条件

参考文献

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