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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Parthenolide
Parthenolide

Chemical Structure : Parthenolide

CAS No.: 20554-84-1

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Parthenolide

货号: PC-25411Not For Human Use, Lab Use Only.

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs.

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50 mg ￥380 In stock
100 mg ￥580 In stock
250 mg ￥980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs.

物理化学性质&存储条件

分子量 248.32
分子式 C15H20O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3aS,9aR,10aR,10bS,E)-6,9a-Dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one

参考文献

1. Zhao WS, et al. Acta Pharmacol Sin. 2023 Aug;44(8):1701-1711.

2. Nakshatri H, et al. Cell Death Dis. 2015 Jan 22;6:e1608.

3. Zhao X, et al. J Exp Clin Cancer Res. 2014 Jan 6;33:3.

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