Paroxetine hydrochloride | GRK2 inhibitor, SSRI | Probechem Biochemicals

Chemical Structure : Paroxetine hydrochloride

CAS No.: 78246-49-8

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Paroxetine hydrochloride (BRL29060 hydrochloride, BRL29060A)

货号: PC-46649Not For Human Use, Lab Use Only.

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.

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500 mg	￥1280	In stock
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生物&药学活性

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.

Paroxetine also is a weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity,

Paroxetine induces autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.

物理化学性质&存储条件

分子量	365.8264
分子式	C19H21ClFNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 250 mg/mL; H2O: 2.12 mg/mL
Chemical Name/SMILES	Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride (1:1), (3S,4R)-

参考文献

1. Thal DM, et al. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.

2. Gassen NC, et al. Autophagy. 2015;11(3):578-80.

3. Alcocer-Gómez E, et al. Pharmacol Res. 2017 Jul;121:114-121.

Paroxetine hydrochloride (BRL29060 hydrochloride, BRL29060A)

生物&药学活性

物理化学性质&存储条件

参考文献

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Paroxetine hydrochloride (BRL29060 hydrochloride, BRL29060A)

生物&药学活性

物理化学性质&存储条件

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