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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-Paroxetine
Paroxetine

Chemical Structure : Paroxetine

CAS No.: 61869-08-7

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Paroxetine (BRL29060)

货号: PC-23760Not For Human Use, Lab Use Only.

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.
Paroxetine also is a weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity,
Paroxetine induces autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.

物理化学性质&存储条件

分子量 329.37
分子式 C19H20FNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

参考文献

1. Thal DM, et al. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.

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