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首页-小分子抑制剂&激动剂-GPCR-Protease-activated Receptor (PAR)-Parmodulin 2
Parmodulin 2

Chemical Structure : Parmodulin 2

CAS No.: 423735-93-7

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Parmodulin 2 (ML161, ML 161)

货号: PC-62640Not For Human Use, Lab Use Only.

Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.
Parmodulin 2 promotes biased PAR1 signaling by preferentially blocking Gαq- over Gα12/13-mediated PAR1 signaling, restricts mTORC1 and Nlrp3 inflammasome activation and limited myocardial ischemia-reperfusion injury.

物理化学性质&存储条件

分子量 361.239
分子式 C17H17BrN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-bromo-N-(3-butyramidophenyl)benzamide

参考文献

1. Nazir S, et al. Blood. 2017 Dec 14;130(24):2664-2677.

2. van den Eshof BL, et al. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902.

3. Aisiku O, et al. Blood. 2015 Mar 19;125(12):1976-85.

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