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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Vitamin D Receptor (VDR)-Paricalcitol
Paricalcitol

Chemical Structure : Paricalcitol

CAS No.: 131918-61-1

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Paricalcitol

货号: PC-45906Not For Human Use, Lab Use Only.

Paricalcitol is an analog of 1,25-dihydroxyergocalciferol that acts as a selective vitamin D receptor (VDR) activator.

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1 mg ￥1580 In stock
5 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Paricalcitol is an analog of 1,25-dihydroxyergocalciferol that acts as a selective vitamin D receptor (VDR) activator.
Paricalcitol significantly decreases parathyroid hormone levels with no changes in calcium and phosphorous.
Paricalcitol also reduces serum concentrations of IL-6 and TNF-α compared to baseline; orally active.

物理化学性质&存储条件

分子量 416.6365
分子式 C27H44O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-

参考文献

1. Donate-Correa J, et al. Nefrologia. 2017 Jun 13. pii: S0211-6995(17)30102-9.

2. Ritter C, et al. Kidney Int. 2017 Jul 24. pii: S0085-2538(17)30326-5.

3. Trohatou O, et al. J Cell Mol Med. 2017 Jun 29. doi: 10.1111/jcmm.13180.

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