Paprotrain

Chemical Structure : Paprotrain

CAS No.: 57046-73-8

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货号: PC-22648Not For Human Use, Lab Use Only.

Paprotrain is a selective, reversible inhibitor of KIF20A (mitotic kinesin-like protein 2, MKLP-2, MKlp2) with Ki of 3.4 uM, does not inhibit other members of the kinesin superfamily.

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25 mg	￥1180	In stock
50 mg	￥1880	In stock
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生物&药学活性

Paprotrain is a selective, reversible inhibitor of KIF20A (mitotic kinesin-like protein 2, MKLP-2, MKlp2) with Ki of 3.4 uM, does not inhibit other members of the kinesin superfamily.
Paprotrain exhibits IC50 values of 1.35 μM in basal and 0.83 μM in MT-stimulated ATPase assays.
Paprotrain is cell permeable and incubation with 10 to 50 μM inhibitor results in binucleated cells, a characteristic phenotype similar to that observed following RNAi-mediated depletion of MKLP-2.
Paprotrain induces mitotic spindle defects, perturbs MKLP-2-mediated relocation of the chromosome passenger proteins Aurora B and survivin from the centromeres to the central spindle.
Paprotrain does not impair kinesin family member 4 (Kif4)-mediated translocation of protein regulating cytokinesis 1 (PRC1), which emphasizes its specificity for MKLP-2.

物理化学性质&存储条件

分子量	245.29
分子式	C16H11N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile

参考文献

1. Tcherniuk S, et al. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31.

Paprotrain

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物理化学性质&存储条件

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