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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-PZL-26
PZL-26

Chemical Structure : PZL-26

CAS No.: 2938876-16-3

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PZL-26 (PZL26)

货号: PC-28435Not For Human Use, Lab Use Only.

PZL-26 is a potent and selective, small molecule inhibitor of Lon protease 1 (LONP1) with IC50 of 27 nM, showing very low activity against the 20S proteasome (IC50=7.3 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PZL-26 is a potent and selective, small molecule inhibitor of Lon protease 1 (LONP1) with IC50 of 27 nM, showing very low activity against the 20S proteasome (IC50=7.3 uM).
    PZL-26 forms a covalent bond with the reactive oxygen of Ser855.
    PZL-26 inhibits the proteolytic activity of LONP1.
    PZL-26 is a tool for investigating LONP1 and underscore the critical role of LONP1 in mitochondrial proteostasis and drug resistance.

    物理化学性质&存储条件

    分子量 483.33
    分子式 C23H30BN5O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((R)-1-((R)-4-morpholino-4-oxo-2-(pyrazine-2-carboxamido)butanamido)-4-phenylbutyl)boronic acid

    参考文献

    1. Szilagyi Z, et al. Life Sci Alliance. 2026 Oct 1;9(12):e202503535.

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