PZ09 |CAS:1132609-87-0 Probechem Biochemicals

Chemical Structure : PZ09

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PZ09 (PKC-zeta inhibitor 9;PKC-ζ inhibitor PZ9)

货号: PC-36023Not For Human Use, Lab Use Only.

PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold).

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生物&药学活性

PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold).
PZ09 also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM).
PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.

物理化学性质&存储条件

分子量	423.524
分子式	C25H25N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)aniline

参考文献

1. Trujillo JI, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11.

2. Kajimoto T, et al. Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662.

PZ09 (PKC-zeta inhibitor 9;PKC-ζ inhibitor PZ9)

生物&药学活性

物理化学性质&存储条件

参考文献

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PZ09 (PKC-zeta inhibitor 9;PKC-ζ inhibitor PZ9)

生物&药学活性

物理化学性质&存储条件

参考文献

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