PZ-3022 | PANK3 activator | Probechem Biochemicals

Chemical Structure : PZ-3022

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PZ-3022 (PZ3022)

货号: PC-28328Not For Human Use, Lab Use Only.

PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively.

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生物&药学活性

PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively.
PZ-3022 renders PanK resistant to C3-CoA inhibition in vitro.
PZ-3022 (10 or 30 mg/kg) relieves CoASH sequestration in liver by increasing hepatic CoASH and C2-CoA and decreasing C3-CoA, consistent with the stimulation of TCA cycle flux.
PZ-3022 relieved hepatic CoA sequestration and elevated CoASH and C2-CoA in male propionic acidemia (PA) mice.
PZ-3022 allosterically activates PanK to counteract its inhibition by C3-CoA and normalizes the intracellular concentrations of total CoA, CoASH, and C2-CoA, and reduces C3-CoA in PA liver.

物理化学性质&存储条件

分子量	347.42
分子式	C20H21N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile

参考文献

1. Subramanian C, et al. Sci Transl Med. 2021 Sep 15;13(611):eabf5965.

PZ-3022 (PZ3022)

生物&药学活性

物理化学性质&存储条件

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PZ-3022 (PZ3022)

生物&药学活性

物理化学性质&存储条件

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