PZ-1922 | 5-HT6 antagonist | Probechem Biochemicals

Chemical Structure : PZ-1922

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PZ-1922 (PZ1922)

货号: PC-21667Not For Human Use, Lab Use Only.

PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.

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生物&药学活性

PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.
PZ-1922 reversed scopolamine-induced cognitive deficits in the novel object recognition test. Furthermore, it displayed superior pro-cognitive properties compared to intepirdine (a 5-HT6R antagonist) in the AD model.
PZ-1922, but not intepirdine, restored levels of biomarkers characteristic of the debilitating effects of oAβ.

物理化学性质&存储条件

分子量	376.89
分子式	C22H21ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-Chlorobenzyl)-4-(piperazin-1-yl)-1H-pyrrolo[3,2-c]quinoline

参考文献

1. Katarzyna Grychowska, et al. J Med Chem. 2023 Nov 9;66(21):14928-14947.

PZ-1922 (PZ1922)

生物&药学活性

物理化学性质&存储条件

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PZ-1922 (PZ1922)

生物&药学活性

物理化学性质&存储条件

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