欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-activating Enzyme (E1)-PYZD-4409
PYZD-4409

Chemical Structure : PYZD-4409

CAS No.: 423148-78-1

加入收藏

PYZD-4409 (PYZD4409;PYZD 4409)

货号: PC-43475Not For Human Use, Lab Use Only.

PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.
PYZD-4409 inhibits the ATP-dependent activation of ubiquitin and subsequent transfer of the activated ubiquitin from the E1 to the common human E2 enzyme UBE2E2.
PYZD-4409 blockes the E1-dependent conjugation of ubiquitin to the E2 enzyme cdc3, induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells.
PYZD-4409 decreases tumor weight and volume without untoward toxicity in vivo.

物理化学性质&存储条件

分子量 351.67
分子式 C14H7ClFN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-

参考文献

1. Xu GW, et al. Blood. 2010 Mar 18;115(11):2251-9.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: