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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-PYD-106
PYD-106

Chemical Structure : PYD-106

CAS No.: 1560894-05-4

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PYD-106 (PYD106)

货号: PC-49064Not For Human Use, Lab Use Only.

PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator, enhances the maximal current response of GluN1/GluN2C receptors.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg ￥7980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator with EC50 of 13 uM, enhances the maximal current response of GluN1/GluN2C receptors.
PYD-106 (30 uM) does not alter responses of NMDA receptors containing GluN2A, GluN2B, and GluN2D and has no effect on AMPA and kainate receptors.
PYD-106 was effective concentration of glutamate and glycine increases the response of GluN1/GluN2C NMDA receptors in HEK-293 cells to 221% (EC50=13 uM).
PYD-106 increased opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only had modest effects on glutamate and glycine EC50.
PYD-106 selectively enhanced the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors.

物理化学性质&存储条件

分子量 432.476
分子式 C25H24N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl 4-(3-acetyl-4-hydroxy-1-(2-(2-methyl-1H-indol-3-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

参考文献

1. Khatri A, et al. Mol Pharmacol. 2014 Nov;86(5):548-60.

2. Kaiser TM, et al. Mol Pharmacol. 2018 Feb;93(2):141-156.

3. Zimmerman SS, et al. J Med Chem 57:2334-2356.

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