PXS-6302 | pan-LOX inhibitor | Probechem Biochemicals

Chemical Structure : PXS-6302

CAS No.: 2584947-54-4

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PXS-6302 (PXS6302)

货号: PC-49358Not For Human Use, Lab Use Only.

PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.

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2 mg	￥2580	In stock
5 mg	￥4580	In stock
10 mg	￥7280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-6302 is a more selective inhibitor than β-aminoproprionitrile (BAPN) and is also optimally designed for topical application.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces skin fibrosis in repeat dose bleomycin-induced skin fibrosis in mice.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces collagen deposition and crosslinking in a murine model of excision injury.
Topical application of PXS-6302 (3% PXS-6302 oil in water cream) improves scar appearance with no reduction in tissue strength in porcine models of excision and burn injury.

物理化学性质&存储条件

分子量	265.250
分子式	C10H10F3NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3,4,4-trifluoro-4-(phenylsulfonyl)but-2-en-1-amine

参考文献

1. Nutan Chaudhari, et al. Nat Commun. 2022 Sep 22;13(1):5555.

PXS-6302 (PXS6302)

生物&药学活性

物理化学性质&存储条件

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PXS-6302 (PXS6302)

生物&药学活性

物理化学性质&存储条件

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