PXS-5153A |CAS:2125956-82-1 Probechem Biochemicals

Chemical Structure : PXS-5153A

CAS No.: 2125956-82-1

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PXS-5153A (PXS5153A;PXS 5153A)

货号: PC-35895Not For Human Use, Lab Use Only.

PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.

规格	价格	库存
2 mg	￥1580	In stock
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.
PXS-5153A displays >40-fold selectivity for LOXL2 over both LOX and LOXL1 and >700-fold over other related amine oxidases.
PXS-5153A dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro.
PXS-5153A reduced disease severity and improved liver function by diminishing collagen content and collagen crosslinks in carbon tetrachloride or streptozotocin/high fat diet-induced liver fibrosis models.

物理化学性质&存储条件

分子量	475.404
分子式	C20H25Cl2FN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(1-(4-amino-2-fluorobut-2-en-1-yl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N,N-dimethylbenzenesulfonamide dihydrochloride

参考文献

1. Schilter H, et al. J Cell Mol Med. 2018 Dec 9. doi: 10.1111/jcmm.14074.

PXS-5153A (PXS5153A;PXS 5153A)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PXS-5153A (PXS5153A;PXS 5153A)

生物&药学活性

物理化学性质&存储条件

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