PXS-4787 | pan-LOX inhibitor | Probechem Biochemicals

Chemical Structure : PXS-4787

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PXS-4787 (PXS4748)

货号: PC-49359Not For Human Use, Lab Use Only.

PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.

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生物&药学活性

PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-4787 dose-dependently inhibits lysyl oxidases with IC50 values ranging from 0.2 µM (LOXL4) to 3 µM (LOXL1) and displays comparable inhibitory activity across species.
PXS-4787 selectivity targets lysyl oxidases and is neither an inhibitor of, nor a substrate for, related oxidases.
PXS-4787 (0-10 uM) reduces collagen formation, deposition and crosslinking in primary human dermal fibroblasts cultured in vitro.
PXS-4748 effectively target extracellular LOX without impacting on skin cell phenotype or leading to a compensatory response.

物理化学性质&存储条件

分子量	229.269
分子式	C10H12FNO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-fluoro-4-(phenylsulfonyl)but-2-en-1-amine

参考文献

1. Chaudhari N, et al. Nat Commun. 2022 Sep 22;13(1):5555.

PXS-4787 (PXS4748)

生物&药学活性

物理化学性质&存储条件

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PXS-4787 (PXS4748)

生物&药学活性

物理化学性质&存储条件

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