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首页-小分子抑制剂&激动剂-Others-Other Targets-PXS-4681A
PXS-4681A

Chemical Structure : PXS-4681A

CAS No.: 1478364-87-2

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PXS-4681A (PXS-4681, PXS4681A)

货号: PC-61472Not For Human Use, Lab Use Only.

PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM.
    PXS-4681A displays 250- and 4000-fold selectivity over DAO and LOX.
    PXS-4681A attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie.

    物理化学性质&存储条件

    分子量 296.741
    分子式 C10H14ClFN2O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-4-(2-(aminomethyl)-3-fluoroallyloxy)benzenesulfonamide hydrochloride

    参考文献

    1. Foot JS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74.

    2. Becchi S, et al. Br J Pharmacol. 2017 Jul;174(14):2302-2317.

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