PXL770 | AMPK activator | Probechem Biochemicals

Chemical Structure : PXL770

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PXL770 (PXL 770)

货号: PC-47024Not For Human Use, Lab Use Only.

PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation.

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100 mg		Get quote

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生物&药学活性

PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation.
PXL770 improves glucose metabolism and dyslipidemia in rodent models of metabolic syndrome, and reduces hepatic DNL in vitro and in vivo.
PXL770 ameliorated each of the classical NASH hallmarks, including steatosis, ballooning, inflammation, and fibrogenesis in diet‐induced (DIO) mouse NASH model.

物理化学性质&存储条件

分子量	423.911
分子式	C23H18ClNO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Chloro-4-hydroxy-5-phenyl-3-(5,6,7,8-tetrahydro-1-hydroxy-2-naphthalenyl)thieno[2,3-b]pyridin-6(7H)-one

参考文献

1. Cusi K, et al. Lancet Gastroenterol Hepatol. 2021 Nov;6(11):889-902.

2. Gluais-Dagorn P, et al. Hepatol Commun. 2022 Jan;6(1):101-119.

PXL770 (PXL 770)

生物&药学活性

物理化学性质&存储条件

参考文献

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PXL770 (PXL 770)

生物&药学活性

物理化学性质&存储条件

参考文献

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