PX20606 | FXR agonist | Probechem Biochemicals

Chemical Structure : PX20606

加入收藏

PX20606 (PX-102, PX102)

货号: PC-26702Not For Human Use, Lab Use Only.

PX20606 (PX-102) is a potent, selective FXR agonist with EC50 of 771 nM, 237 nM and 129 nM for mouse, rat, and human FXR in biochemical TR-FRET assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PX20606 (PX-102) is a potent, selective FXR agonist with EC50 of 771 nM, 237 nM and 129 nM for mouse, rat, and human FXR in biochemical TR-FRET assays.
PX20606 (PX-102) has EC50 of 268, 179, 107 and 77 nM in GAL4-FXR-LBD fusion cellular reporter assays using mouse, rat, monkey, and human FXR-LBDs.
PX20606 potently lowered total cholesterol and, despite the observed HDL cholesterol (HDLc) reduction, caused a highly significant decrease in atherosclerotic plaque size, in CETPtg-LDLR(−/−) mice.
PX20606 reduced total cholesterol, specifically lowered HDL2c but not HDL3c or apolipoprotein A1, in normolipidemic cynomolgus monkeys. ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.

物理化学性质&存储条件

分子量	554.85
分子式	C29H22Cl3NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]benzoic acid

参考文献

1. Hambruch E, et al. J Pharmacol Exp Ther. 2012 Dec;343(3):556-67.

2. Schwabl P, et al. J Hepatol. 2017 Apr;66(4):724-733.

PX20606 (PX-102, PX102)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PX20606 (PX-102, PX102)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.