PWZ-029 | α5-GABAAR inverse agonist | Probechem Biochemicals

Chemical Structure : PWZ-029

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PWZ-029 (PWZ029)

货号: PC-62625Not For Human Use, Lab Use Only.

PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo.

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生物&药学活性

PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo.
PWZ-029 successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone.

物理化学性质&存储条件

分子量	291.735
分子式	C14H14ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

参考文献

1. Savić MM, et al. Brain Res. 2008 May 7;1208:150-9.

2. Milić M, et al. Behav Brain Res. 2013 Mar 15;241:206-13.

3. Soto PL, et al. Neuropsychopharmacology. 2013 Oct;38(11):2315-25.

4. Timić Stamenić T, et al. J Psychopharmacol. 2015 Sep;29(9):1013-24.

PWZ-029 (PWZ029)

生物&药学活性

物理化学性质&存储条件

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PWZ-029 (PWZ029)

生物&药学活性

物理化学性质&存储条件

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