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首页-小分子抑制剂&激动剂-Others-Other Targets-PW0729
PW0729

Chemical Structure : PW0729

CAS No.: 2767348-23-0

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PW0729 (PW-0729)

货号: PC-22470Not For Human Use, Lab Use Only.

PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.
PW0729 shows EC50 of 110 nM in β-arrestin recruitment assay.
PW0729 is highly selective for GPR52 agonism with no significant off-target effects at other brain GPCRs.
PW0729 is also bioavailable but hs less than optimal brain permeability, requiring further optimization.

物理化学性质&存储条件

分子量 415.42
分子式 C22H20F3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-Hydroxyethyl)-3-((4-(3-(trifluoromethyl)benzyl)pyridin-2-yl)amino)benzamide

参考文献

1. Ryan E Murphy, et al. J Med Chem. 2024 Jun 13;67(11):9709-9730.

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