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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Kinesin-PVZB1194
PVZB1194

Chemical Structure : PVZB1194

CAS No.: 1141768-04-8

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PVZB1194 (PVZB-1194)

货号: PC-62339Not For Human Use, Lab Use Only.

PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
    PVZB1194  inhibits HeLa cell proliferation with IC50 of 5.5 uM.
    PVZB1194  potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.

    物理化学性质&存储条件

    分子量 319.274
    分子式 C13H9F4NO2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[3-fluoro-4-(trifluoromethyl)phenyl]benzenesulfonamide

    参考文献

    1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61.

    2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.

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