PV-1019 |CAS:1093793-05-5 Probechem Biochemicals

Chemical Structure : PV-1019

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PV-1019 (NSC-744039;NSC744039;PV1019)

货号: PC-60283Not For Human Use, Lab Use Only.

PV-1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.

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生物&药学活性

PV-1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
PV-1019 displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1.
PV-1019 inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage.
PV-1019 protects normal mouse thymocytes against ionizing radiation-induced apoptosis.

物理化学性质&存储条件

分子量	379.38
分子式	C18H17N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide

参考文献

1. Jobson AG, et al. J Pharmacol Exp Ther. 2009 Dec; 331(3):816-26.

PV-1019 (NSC-744039;NSC744039;PV1019)

生物&药学活性

物理化学性质&存储条件

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PV-1019 (NSC-744039;NSC744039;PV1019)

生物&药学活性

物理化学性质&存储条件

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