PUC-10

Chemical Structure : PUC-10

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货号: PC-24220Not For Human Use, Lab Use Only.

PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy.

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生物&药学活性

PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy.

物理化学性质&存储条件

分子量	541.67
分子式	C31H31N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(1-(naphthalen-1-ylsulfonyl)-1 H-indol-3-yl)ethan-1-ol

参考文献

1. Alcaíno JM, et al. Sci Rep. 2025 Mar 11;15(1):8380. doi: 10.1038/s41598-025-92755-6.

2. Vera, G. et al. Extended N-Arylsulfonylindoles as 5-HT6 receptor antagonists: design, synthesis and biological evaluation. Molecules 21 (8). https://doi.org/10.3390/molecules21081070 (2016).

PUC-10

生物&药学活性

物理化学性质&存储条件

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PUC-10

生物&药学活性

物理化学性质&存储条件

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