PU-H71 | Hsp90 inhibitor | Probechem Biochemicals

Chemical Structure : PU-H71

CAS No.: 873436-91-0

加入收藏

PU-H71 (Zelavespib, NSC 750424)

货号: PC-72710Not For Human Use, Lab Use Only.

PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.
PU-H71 inhibits cell growth in a range of breast cancer cell lines with IC50 values of 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells, respectively.
PU-H71 inhibits cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
PU-H71 demonstrated anti-lymphoma activity and showed synergistic effect with dual PI3K/mTOR inhibition in vitro and in vivo.

物理化学性质&存储条件

分子量	512.37
分子式	C18H21IN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (51.2 mg/mL)
Chemical Name/SMILES	8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine

参考文献

1. Huazhong He, et al. J Med Chem. 2006 Jan 12;49(1):381-90.

2. Eloisi Caldas-Lopes, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73.

3. Carmel T Chan, et al. Cancer Res. 2008 Jan 1;68(1):216-26.

4. Giulino-Roth L, et al. Mol Cancer Ther. 2017 Sep;16(9):1779-1790.

PU-H71 (Zelavespib, NSC 750424)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PU-H71 (Zelavespib, NSC 750424)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.