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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-PU-141
PU-141

Chemical Structure : PU-141

CAS No.: 168334-34-7

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PU-141 (PU141, PU 141)

货号: PC-61685Not For Human Use, Lab Use Only.

PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3680 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM.
PU-141 blocks growth of SK-N-SH neuroblastoma xenografts in mice.
PU-141 also reduces histone lysine acetylation in vivo at concentrations that block neoplastic xenograft growth.

物理化学性质&存储条件

分子量 310.294
分子式 C14H9F3N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one

参考文献

1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137.

2. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.

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