PU-139 |CAS:158093-65-3 Probechem Biochemicals

Chemical Structure : PU-139

CAS No.: 158093-65-3

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PU-139 (PU139;PU 139)

货号: PC-61686Not For Human Use, Lab Use Only.

PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300.
PU-139 triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo.

物理化学性质&存储条件

分子量	246.259
分子式	C12H7FN2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one

参考文献

1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137.

2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116.

3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.

PU-139 (PU139;PU 139)

生物&药学活性

物理化学性质&存储条件

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PU-139 (PU139;PU 139)

生物&药学活性

物理化学性质&存储条件

参考文献

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