PTPN22 inhibitor NC1

Chemical Structure : PTPN22 inhibitor NC1

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货号: PC-21074Not For Human Use, Lab Use Only.

PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells.

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生物&药学活性

PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells.
PTPN22 inhibitor NC1 displays at least 1.9-fold higher selectivity against a panel of other protein phosphatases, including STEP, PTPN18, Glepp, VHR, and the Ser/Thr phosphatases PPM1A and PP1.
PTPN22 inhibitor NC1 (20 uM) significantly increased the phosphorylation levels of ERK and LCK in Jurkat T cells, shows no effect on CD3-induced LCK and ERK phosphorylation in T cells without endogenous LYP expression.

物理化学性质&存储条件

分子量	546.59
分子式	C29H26N2O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(COC2=CC=C(/C=C(S/C(N3C)=N/C4=CC=C(C(OCC)=O)C=C4)/C3=O)C=C2OC)C=C1

参考文献

1. Li K, et al. J Biol Chem. 2019 May 24;294(21):8653-8663.