PTPN22 inhibitor L-1

Chemical Structure : PTPN22 inhibitor L-1

CAS No.: 2580935-57-3

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货号: PC-72034Not For Human Use, Lab Use Only.

PTPN22 inhibitor L-1 is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PTPN22 inhibitor L-1 is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs.
PTPN22 inhibitor L1 phenocopied the antitumor effects seen in genotypic PTPN22 knockout.
PTPN22 inhibition via PTPN22 inhibitor L1 promoted activation of CD8+ T cells and macrophage subpopulations toward MHC-II expressing M1-like phenotypes, both of which were necessary for successful antitumor efficacy.
Targeting PTPN22 via PTPN22 inhibitor L1 is nonredundant with and augments anti–PD-1 therapy.

物理化学性质&存储条件

分子量	455.47
分子式	C26H21N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(2-([1,1'-biphenyl]-4-carboxamido)propanamido)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

参考文献

1. Won Jin Ho, et al. J Clin Invest. 2021 Jul 20;131(17):e146950.