PTPN22 inhibitor 8b

Chemical Structure : PTPN22 inhibitor 8b

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货号: PC-23638Not For Human Use, Lab Use Only.

PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs.
PTPN22 inhibitor 8b possesses highly efficacious cellular activity in both T- and mast cells and is capable of blocking anaphylaxis in mice.

物理化学性质&存储条件

分子量	501.92
分子式	C28H20ClNO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Benzofurancarboxylic acid, 3-[2-(3-chlorophenyl)ethynyl]-2-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]-6-hydroxy-

参考文献

1. He Y, et al. J Med Chem. 2013 Jun 27;56(12):4990-5008.