PTPN22 inhibitor 8b-19

Chemical Structure : PTPN22 inhibitor 8b-19

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货号: PC-23637Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PTPN22 inhibitor 8b-19 is a potent, selective inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22) with IC50 of 0.25 uM, 15.2-fold and 19.2-fold selectivity against SHP2 and PTP1B, respectively.
PTPN22 inhibitor 8b-19 displays little to no activity against an extended panel of mammalian PTPs including nonreceptor PTPs, SHP1, TCPTP, MEG2, PEST, HePTP, and FAP-1, receptor-like PTPs, PTPα and PTPε, dual specificity PTPs, VHZ and Laforin, and the low molecular weight PTP.
PTPN22 inhibitor 8b-19 (10 uM) increases T cell signaling in a dose-response manner, induces greater levels of phosphorylated LCK and ERK1/2 in Jurkat cells.

物理化学性质&存储条件

分子量	503.94
分子式	C28H22ClNO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-chlorostyryl)-2-(4-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-6-hydroxybenzofuran-5-carboxylic acid

参考文献

1. Jassim BA, et al. Eur J Med Chem. 2024 Dec 6;283:117129.