PTP1B inhibitor BDB

Chemical Structure : PTP1B inhibitor BDB

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货号: PC-20470Not For Human Use, Lab Use Only.

PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM.
PTP1B inhibitor BDB binds to PTP1B with an affinity of 1.812 μM and in a slow‐on and slow‐off manner in SPR assays.
PTP1B inhibitor BDB enhances the stability of PTP1B, protects PTP1B from pronase‐induced proteolysis.
PTP1B inhibitor BDB is selective for PTP1B over other PTPs (TC‐PTP, SHP‐1, SHP‐2, and LAR).
PTP1B inhibitor BDB (50 and 100 mg/kg/day, oral, 9 weeks) protects PTP1B protein from temperature‐dependent degradation at the intact‐cell level.
PTP1B inhibitor BDB prevents hyperglycaemia in diabetic BKS db mice, improves glucose clearance and significantly decreases insulin resistance in diabetic mice.

物理化学性质&存储条件

分子量	748.84
分子式	C20H13Br5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol

参考文献

1. Jiao Luo, et al. Br J Pharmacol. 2020 Oct;177(19):4464-4480.