PTP1B-IN-5b |CAS:2101230-45-7 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-PTP1B-IN-5b

Chemical Structure : PTP1B-IN-5b

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PTP1B-IN-5b

货号: PC-62844Not For Human Use, Lab Use Only.

PTP1B-IN-5b is a potent protein tyrosine phosphatase PTP1B inhibitor with IC50 of 5.25 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PTP1B-IN-5b is a potent protein tyrosine phosphatase PTP1B inhibitor with IC50 of 5.25 uM.
PTP1B-IN-5b shows remarkable cytotoxic activity at 0.09 uM of IC50 against the MCF-7 cell line.
PTP1B-IN-5b also showed potential anticancer activity against MCF-7 (IC50=2.22 uM) and HepG2 (IC50=0.72 uM) cell lines as well as PTP1B inhibitory activity with IC50 of 6.37 uM.

物理化学性质&存储条件

分子量	417.479
分子式	C24H19NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-(4-(2-naphthamido)phenyl)-3-methoxythiophene-2-carboxylate

参考文献

1. Gulipalli KC, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3558-3564.

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PTP1B-IN-5b

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物理化学性质&存储条件

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PTP1B-IN-5b

生物&药学活性

物理化学性质&存储条件

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