PTP1B-IN-2 | PTP1B inhibitor | Probechem Biochemicals

Chemical Structure : PTP1B-IN-2

CAS No.: 1919853-46-5

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PTP1B-IN-2 (PTP1B inhibitor P6)

货号: PC-20596Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥2980	In stock
100 mg	￥6580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP.
PTP1B-IN-2 (15 and 30 uM) greatly enhances insulin-mediated IRβ phosphorylation, significantly increases insulin-stimulated glucose uptake in L6 myotube.

物理化学性质&存储条件

分子量	680.79
分子式	C34H36N2O9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OC)C1=CC(N(CC2=CC=C(N(CC(OC)=O)S(=O)(C)=O)C=C2)S(=O)(CC3=CC=CC=C3)=O)=CC=C1OCC4=CC=C(C)C=C4

参考文献

1. Peihong Liu, et al. Eur J Med Chem. 2016 Aug 8;118:27-33.

PTP1B-IN-2 (PTP1B inhibitor P6)

生物&药学活性

物理化学性质&存储条件

参考文献

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PTP1B-IN-2 (PTP1B inhibitor P6)

生物&药学活性

物理化学性质&存储条件

参考文献

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