PTG-0861 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : PTG-0861

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PTG-0861 (PTG0861, JG-265)

货号: PC-72089Not For Human Use, Lab Use Only.

PTG-0861 (JG-265) is a novel potent, selective HDAC6 inhibitor with IC50 of 5.92 nM, >36-fold selectivity over other HDACs.

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生物&药学活性

PTG-0861 (JG-265) is a novel potent, selective HDAC6 inhibitor with IC50 of 5.92 nM, >36-fold selectivity over other HDACs.
PTG-0861 (JG-265) displays HDAC6 cellular target engagement with EC50 of 0.59 uM (ELISA), has in vitro and cellular selectivity superior to HDAC6-selective inhibitor citarinostat (ACY-241).
PTG-0861 (JG-265) demonstrates potency against several blood cancer cell lines (e.g. MV4-11, MM1S), whilst showing limited cytotoxicity against non-malignant cells and CD-1 mice.
PTG-0861 (JG-265) exihibits promising in vitro pharmacokinetics achieved with good safety profile in cells and in vivo.

物理化学性质&存储条件

分子量	360.24
分子式	C15H9F5N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2,3,4,5,6-pentafluoro-N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-

参考文献

1. Justyna M Gawel, et al. Eur J Med Chem. 2020 Sep 1;201:112411.

PTG-0861 (PTG0861, JG-265)

生物&药学活性

物理化学性质&存储条件

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PTG-0861 (PTG0861, JG-265)

生物&药学活性

物理化学性质&存储条件

参考文献

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