PTERi | PTER inhibitor | Probechem Biochemicals

Chemical Structure : PTERi

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PTERi (PTER inhibitor)

货号: PC-26061Not For Human Use, Lab Use Only.

PTERi (PTER inhibitor) is a potent, seletive inhibitor of PTER (phosphotriesterase-related) with IC50 of 43 nM (recombinant mouse PTER activity), >100-fold selectivity for PTER over HDACs and sirtuin (SIRT) deacetylases in vitro.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PTERi (PTER inhibitor) is a potent, seletive inhibitor of PTER (phosphotriesterase-related) with IC50 of 43 nM (recombinant mouse PTER activity), >100-fold selectivity for PTER over HDACs and sirtuin (SIRT) deacetylases in vitro.
PTERi also inhibits human (IC50=830 nM), rat, and sponge PTER enzymes with IC50 concentrations in the nanomolar range.
PTERi enhances GLP1-RA (glucagon like peptide 1 receptor agonist)-induced weight loss, and prevents weight regain after GLP1-RA discontinuation in diet-induced obese mice reduces feeding.

物理化学性质&存储条件

分子量	372.38
分子式	C19H20N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethoxy)ethoxy)-N-hydroxypropanamide

参考文献

1. Fu S, et al. bioRxiv [Preprint]. 2026 Jan 28:2026.01.26.701829.