PTC-596 (Unesbulin) | BMI-1 inhibitor | Probechem Biochemicals

Chemical Structure : PTC-596

CAS No.: 1610964-64-1

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PTC-596 (Unesbulin, PTC 596, PTC596)

货号: PC-60486Not For Human Use, Lab Use Only.

PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.
PTC-596 is a direct microtubule polymerization inhibitor.
PTC-596 reduces total BMI-1 protein levels by 87% and 61% in MOLM-13 and OCI-AML3 cells at 100 nM, induces apoptosis and reduces the levels of ubiquitylated histone H2A.
PTC-596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

物理化学性质&存储条件

分子量	420.347
分子式	C19H13F5N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine

参考文献

1. Nishida Y, et al. Blood Cancer J. 2017 Feb 17;7(2):e527.

2, Eberle-Singh JA, et al. Clin Cancer Res. 2019 Jun 7. pii: clincanres.3281.2018. doi: 10.1158/1078-0432.CCR-18-3281.

3, Maeda A, et al. Oncotarget. 2018 Jun 19;9(47):28547-28560.

PTC-596 (Unesbulin, PTC 596, PTC596)

生物&药学活性

物理化学性质&存储条件

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PTC-596 (Unesbulin, PTC 596, PTC596)

生物&药学活性

物理化学性质&存储条件

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